Lathosterol and other non-cholesterol sterols during treatment of hypercholesterolaemia with beta-glucan-rich oat bran

Lathosterol and other noncholesterol sterols during treatment of hypercholesterolemia with lovastatin alone and with cholestyramine or guar gum.

Sixty-two patients aged 19-64 years with primary hypercholesterolemia (mean level of total cholesterol, 10.8 mmol/l) were treated with 80 mg/day lovastatin (L) alone for 18 weeks and, after randomization to either L + 20 g/day guar gum (L + GG) or L + 16 g/day cholestyramine (L + C) treatments, for an additional 18 weeks. The total cholesterol level declined from baseline by 34% during L and by...

Health from grain: oat beta-glucan

Lantmännen is a Swedish cooperative owned by 27,000 farmers. Research has always been regarded as important within the cooperative; therefore, Lantmännen has its own research foundation allowing for investment in both external and internal research. Oats are one food crop that has been studied because its components have possible health effects. It has been known since the nineteenth century th...

Biosynthesis of Cholesterol and Other Sterols

4.5. C24-Alkylation Reduction Bifurcation in Phytosterol Synthesis 6433 5. Sterol Enzyme Action 6434 5.1. C24 Methylation 6434 5.2. C24-Reduction 6438 5.3. Removal of Nuclear Methyl Groups at C4 6439 5.4. Removal of Nuclear Methyl Group at C14 6441 5.5. Shift of Δ to Δ-Position 6442 5.6. 9β,19-Cyclopropane Ring Opening 6444 5.7. C22 Desaturation 6444 6. Concluding Remarks 6445 Author Informatio...

Soluble fibre oat and barley beta-glucan enriched products: can we predict cholesterol-lowering effects?

Amelioration of cardiovascular risk through a high intake of dietary fibre was originally highlighted by Ancel Keys and colleagues in the Journal of Nutrition in 1960 (Keys et al. 1960). More than 45 years later there is a growing body of evidence supporting the association between intake of whole grains and decreased incidence of fatal and nonfatal CHD (Liu et al. 1999; Steffen et al. 2003; Je...

Author's response to reviews Title: Bioactive oat beta-glucan reduces LDL cholesterol in Caucasians and non-Caucasians. Authors: